Sugar Nanoparticles Reduce Inflammation Caused by Strokes



Sugar-Nanoparticles Reduce Inflammation

Buckyballs combined with the amino sugar


New research finds that amino sugar nanoparticles reduce inflammation and cell damage caused by a stroke.

A stroke is when brain tissue becomes deprived of oxygen by a blood clot or rupture causing bleeding. The reduced or blocked blood flow starves tissue downstream of the blockage causing tissue damage. Tissue damage in turn causes inflammation resulting in even greater brain damage. Reducing inflammation damage could improve the prognosis of stroke patients leading to faster recovery after strokes. New research from FECYT – Spanish Foundation for Science and Technology, have used a combination of amino sugar and nanoparticles to reduce the cell damage caused by strokes.

Sugar-Nanoparticles Reduce Inflammation

Researchers discover that a combination of two substances help reduce inflammation and the volume of brain tissue affected following a stroke. The two substances: glucosamine, an amino sugar commonly used to treat arthrosis and arthritis, and fullerenes, also called buckyballs, which are round hollow carbon structures.

Researchers landed at these two substances since it’s known that buckyballs have the ability to capture radicals, highly reactive atoms formed by oxidative stress, and glucosamine to reduce inflammation.

Combining the two compounds formed glyconanoparticles. Theses sugar nanoparticles were administered to rats with induced strokes to test their effectiveness as a treatment. Using MRI scans to visualize the damage and behavior to track improvement of neurological symptoms in rats recovering from the strokes, researchers concluded that rats treated with the sugar nanoparticles had less cell damage and inflammation compared to controls. The findings were published in the journal Experimental Neurology.

“Although the present study was carried out on mice, the results indicate that these sweet buckyballs are potential new drugs for treating Stroke also in humans. However, this must be taken with caution, since what works in mice does not necessarily will work in the same way in humans,” declared Orts-Gil.

Image Credit: MPIKG